如何在Notepad++中删除匹配指定内容的文本（含重复与唯一行）

Got it, let's tackle this problem step by step—you need to wipe out every single line (whether it's a duplicate or unique entry) that includes any of your 100+ target email addresses in Notepad++. Here's the most efficient way to do it:

Step 1: Turn Your Email List into a Regex Pattern #

Since you have dozens of emails to match, we'll use a regular expression with "OR" logic to catch all of them at once:

1. Take your list of target emails (e.g., test1@test.com, test3@test.com, test5@test.com).
2. For each email, escape the dot characters (. becomes \.) because in regex, a dot matches any character. So test1@test.com becomes test1@test\.com.
3. Join all these escaped emails with a pipe | (this means "match any of these"). Your final pattern snippet will look like:

   test1@test\.com|test3@test\.com|test5@test\.com|...
   

Step 2: Use Notepad++'s Find/Replace with Regex #

Now let's apply this to delete the matching lines:

• Open your target file in Notepad++.
• Press Ctrl+H to open the Find/Replace dialog.
• In the Search Mode section, select Regular expression (make sure the . matches newline box is unchecked—we don't want to match across lines).
• In the Find what field, wrap your regex snippet with ^.* and .*$ to match the entire line that contains any of your target emails. The full pattern will look like:

  ^.*(test1@test\.com|test3@test\.com|test5@test\.com|...).*$
  

• Leave the Replace with field completely empty—this tells Notepad++ to delete the matched lines.
• Click Replace All—boom, every line with any of your target emails (duplicate or unique) will be removed instantly.

Pro Tip to Avoid Mistakes #

Before hitting Replace All, click Find All in Current Document to preview exactly which lines will be deleted. This lets you double-check that your regex is targeting the right lines before making changes. Always back up your original file too—better safe than sorry!

内容的提问来源于stack exchange，提问作者Stew