Hey there! I totally get the annoyance of leftover files after trying to uninstall a program—let's get this Wine issue sorted for you properly, since you're using an apt-based system (like Ubuntu or Debian):

第一步：彻底清理Wine的系统级组件 #

The regular sudo apt remove wine only deletes the base package but leaves behind config files and unused dependencies. Instead, run these commands one by one:

1. Purge all Wine-related packages along with their configuration files:

   sudo apt purge wine*
   

   The * wildcard makes sure we catch every Wine variant (like wine-stable, wine-devel, etc.) that might be installed.
2. Remove any leftover dependencies that were installed just to support Wine:

   sudo apt autoremove --purge
   

   The --purge flag ensures we don't leave behind any stray configs from those dependencies either.

第二步：清理用户专属的Wine配置文件 #

Wine stores personal settings and app data in your home directory too—delete these with:

rm -rf ~/.wine
rm -rf ~/.local/share/wine
rm -rf ~/.config/wine

关于/usr/lib/wine文件夹的安全性 #

That leftover wine folder in /usr/lib/ is just a remnant of the original Wine installation, and it's completely safe to delete manually if the above commands didn't take care of it. The /usr/lib/x86_64-linux-gnu directory (you mentioned "x86 64 linux gnu") is where 64-bit system libraries live, but the wine subfolder only contains Wine-specific files—removing it won't harm your system at all.

To delete it, run:

sudo rm -rf /usr/lib/wine

确认是否完全卸载 #

You can double-check if any Wine packages are still lingering with this command:

dpkg --list | grep wine

If no results show up, you've successfully removed Wine entirely!

备注：内容来源于stack exchange，提问作者TheArchCoder