Ubuntu17.10 Miniconda环境下安装DESeq2报错求助（已装依赖）

Hey there, let's work through this DESeq2 installation snag you're hitting. Since you've already got libxml2-dev and libcurl4-openssl-dev installed, and you've located the libcurl.pc file, here are some focused fixes to try:

• Point R directly to your system's libcurl config file
  Miniconda environments sometimes prioritize their own libraries over system-installed ones, which might be why R isn't picking up your existing libcurl setup. In your R session, set the PKG_CONFIG_PATH to the directory containing libcurl.pc first (replace the path below with your actual directory if it's different):

  Sys.setenv(PKG_CONFIG_PATH="/usr/lib/x86_64-linux-gnu/pkgconfig/")
  # Then use BiocManager (the replacement for biocLite) to install
  if (!require("BiocManager", quietly = TRUE))
      install.packages("BiocManager")
  BiocManager::install("DESeq2")
  

• Skip source compilation entirely with Conda's pre-built package
  Compiling from source is often where dependency issues pop up. Instead, install the Conda-maintained version of DESeq2 directly in your environment—this handles all dependencies automatically:

  conda install -c bioconda bioconductor-deseq2
  

• Ensure your Conda environment has proper compilation tools
  If you still want to install via BiocManager, make sure your Conda environment has the GCC/G++ compilers needed to build R packages from source:

  conda install gcc_linux-64 gxx_linux-64
  

  After installing these, restart your R session and try the DESeq2 installation again.

• Check R version compatibility
  Ubuntu 17.10 ships with an older R version, and DESeq2 has strict R version requirements (e.g., newer DESeq2 versions need R ≥ 4.0). Try upgrading R in your Conda environment to a compatible version first:

  conda install r-base=4.1  # Adjust version based on DESeq2's requirements
  

  Then proceed with the BiocManager installation.

内容的提问来源于stack exchange，提问作者cpat