网站突发无法加载，报Cannot load a reference assembly for execution错误求助

Hey there, let’s work through this "Cannot load a reference assembly for execution" error you’re facing with your site on VS2017 and .NET Framework 4.7.1. Here are practical, tested fixes to resolve this issue:

• Fix misconfigured assembly references
  Sometimes assemblies get marked as "reference-only," which prevents them from being copied to the output directory at runtime.
  Right-click your project → References → Find the problematic assembly → Right-click Properties → Make sure Copy Local is set to True, and uncheck Specific Version (unless you explicitly need a fixed version).

• Clean and rebuild your solution
  Stale build cache often causes weird runtime issues:

  1. Go to VS top menu → Build → Clean Solution
  2. Manually delete the bin and obj folders from your project directory
  3. Restart VS, then click Rebuild Solution

• Repair .NET Framework 4.7.1 installation
  A corrupted .NET installation might be the root cause:

  • Open Control Panel → Programs and Features → Find ".NET Framework 4.7.1" → Right-click Change → Select Repair
  • If repair doesn’t work, uninstall it and download a fresh copy of .NET Framework 4.7.1 compatible with Windows 10 Home.

• Verify project target framework
  Double-check your project is actually targeting .NET 4.7.1:
  Right-click your project → Properties → Application tab → Under Target framework, select .NET Framework 4.7.1, save changes, and rebuild.

• Check web.config assembly binding redirects (for web projects)
  Incorrect binding redirects in web.config can block assembly loading. Open your web.config, locate the <runtime> → <assemblyBinding> section. Ensure the version redirects for your assemblies are correct, like this example:

  <dependentAssembly>
    <assemblyIdentity name="YourAssemblyName" publicKeyToken="your-token-here" culture="neutral" />
    <bindingRedirect oldVersion="0.0.0.0-1.0.0.0" newVersion="1.0.0.0" />
  </dependentAssembly>
  

  If you’re unsure, try commenting out suspicious redirects temporarily to test if the site loads.

• Dig into detailed error logs
  Open VS’s Output Window (View → Output), switch to the Build or Debug output stream. Look for specific assembly names that failed to load—this will help you target the exact issue faster.

内容的提问来源于stack exchange，提问作者Krunal