加权KM估计差异:svykm与survfit结果不一致的技术问询
病例对照研究中加权与未加权Kaplan-Meier曲线不重叠问题及实现代码
我在病例对照研究中使用权重开展生存分析,所有病例的权重设为1。但绘制加权与未加权Kaplan-Meier(KM)曲线时,发现病例组的KM曲线并未重叠。以下是使用survival包实现的完整流程代码,涵盖权重计算、三种KM估计(朴素survfit、带权重的survfit、svykm)及曲线绘制、结果提取:
library(dplyr) library(tidyverse) library(survival) library(broom) library(WeightIt) library(survey) a <- survival::ovarian # 计算权重: weights <- WeightIt::weightit(rx ~ age + ecog.ps + resid.ds, int = T, estimand = "ATT", data = a, method = "glm" , stabilize = F, missing = "saem") a$weights <- weights$weights a$ps <- weights$ps design <- svydesign(ids = ~ 1, data = a, weights = ~weights) KM_PFS <- survfit(Surv(futime, fustat > 0)~rx, a) # 朴素KM估计 KM_PFS_w_TT <- survfit(Surv(futime, fustat > 0)~rx, a, weights = weights, robust = T) KM_PFS_w <- svykm(Surv(futime, fustat > 0)~rx, design = design,se=T) par(mfrow=c(1,1)) plot(KM_PFS_w[[2]], lwd=2, col=c("red"),xlab="时间(月)",ylab="无进展生存期(PFS)",#svykm处理组 xaxt="n", ci=F) #lines(KM_PFS_w[[1]],col=c("blue"),lwd=2) lines(KM_PFS,col=c("black","black"),lwd=2,lty=c(0,2)) # 朴素KM处理组 lines(KM_PFS_w_TT,col=c("orange","violet"),lwd=2,lty=c(0,1))# 加权TT KM处理组 cas_km_w_TT <- tidy(KM_PFS_w_TT)%>%filter(strata == "rx=1") cas_km <- tidy(KM_PFS)%>%filter(strata == "rx=1") cas_km_w <- do.call("rbind", lapply(names(KM_PFS_w), \(x) { data.frame(strata = x, do.call("cbind", KM_PFS_w[[x]])) })) %>% filter(strata ==1)
内容的提问来源于stack exchange,提问作者SofiaB
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