安装R包ChemmineOB失败：找不到openbabel/obutil.h文件求助

环境信息 #

• 已成功安装BiocManager和ChemmineR
• 通过brew安装OpenBabel 3.1.0，头文件路径：~/local/include/openbabel-2.0/openbabel/
• R版本：4.4.0
• Bioconductor版本：3.19

执行的安装代码 #

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("ChemmineOB")

报错信息 #

ChemmineOB.cpp:1569:10: fatal error: 'openbabel/obutil.h' file not found
#include <openbabel/obutil.h>
         ^~~~~~~~~~~~~~~~~~~~
1 error generated.
make: *** [ChemmineOB.o] Error 1

额外输出信息 #

'getOption("repos")' replaces Bioconductor standard repositories, see 'help("repositories", package = "BiocManager")' for details.
Replacement repositories:
    CRAN: https://cran.rstudio.com/
Bioconductor version 3.19 (BiocManager 1.30.23), R 4.4.0 (2024-04-24)
Installing package(s) 'ChemmineOB'
Warning: downloaded length 0 != reported length 11310Warning: cannot open URL 'https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.4/PACKAGES.rds': HTTP status was '404 Not Found'Warning: downloaded length 0 != reported length 11310Warning: cannot open URL 'https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.4/PACKAGES.gz': HTTP status was '404 Not Found'Package which is only available in source form, and may need compilation of C/C++/Fortran: ‘ChemmineOB’

疑问 #

明明obutil.h存在于指定路径中，但编译时系统无法识别该文件，该如何解决？

内容的提问来源于stack exchange，提问作者Jrbald